https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51411 Wed 28 Feb 2024 15:41:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6281 Wed 11 Apr 2018 16:43:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29013 P < 2 × 10⁻¹⁶). Further, the gene set analyses revealed several miRNAs regulating schizophrenia risk genes, with the strongest enrichment for targets of miR-9-5p (P = .0056 for enrichment among the top 1% most-associated single-nucleotide polymorphisms, corrected for multiple testing). It is further of note that MIR9-2 is located in a genomic region showing strong evidence for association with schizophrenia (P = 7.1 × 10⁻⁸). The second and third strongest gene set signals were seen for the targets of miR-485-5p and miR-137, respectively. Conclusions and Relevance: This study provides evidence for a role of miR-9-5p in the etiology of schizophrenia. Its implication is of particular interest as the functions of this neurodevelopmental miRNA tie in with established disease biology: it has a regulatory loop with the fragile X mental retardation homologue FXR1 and regulates dopamine D₂ receptor density.]]> Wed 11 Apr 2018 15:28:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13896 Wed 11 Apr 2018 14:01:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22038 Wed 11 Apr 2018 12:26:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53426 Wed 03 Apr 2024 14:49:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20582 Sat 24 Mar 2018 07:55:36 AEDT ]]>